You can titrate to higher doses without adding more pills. Patients can be titrated up to Forfivo XL 450 mg once daily if they have been taking 300 mg per day of bupropion for at least 2 weeks and require a dosage of 450 mg per day.


Forfivo XL® provides a once-daily, bupropion 450 mg dose in a single tablet:
  • Indicated for the treatment of major depressive disorder
  • Proven bioequivalent to Wellbutrin XL®1
  • One Forfivo XL 450 mg tablet per day is equivalent to Wellbutrin XL 3 X 150 mg
Maintenance Therapy:
  • It is not known whether the 450 mg dose needed to achieve initial response is needed for maintenance treatment
  • Patients should be periodically reassessed to determine the need for a maintenance treatment and the appropriate dose for such patients

Therapy Initiation:
  • Patients currently treated with other bupropion products may be switched to Forfivo XL if they are receiving:
    • 450 mg/day
    • 300 mg/day for a least two weeks and requiring a dose increase to 450 mg/day
  • Do not initiate bupropion therapy with Forfivo XL because 450 mg is the only available dosage strength. Use another lower dose bupropion product for initial dose titration.
Rx Savings Program:
  • Rx Savings Program will automatically limit 30-day Rx cost to $28 for most commercial drug plan patients*
    • Some patients may still need a physical copay savings card to reduce their cost
    • Copay cards can be downloaded on this page

Please see below for Important Safety Information, including Boxed Warning, and accompanying full prescribing information

*Maximum savings benefit up to $155 for ≤59 tablets; up to $310 for 60-89 tablets; or up to $465 for ≥90 tablets. Certain patient groups are not eligible for this Rx Savings Program (e.g., federal healthcare programs, including Medicare or Medicaid, Medicare Part D prescription drug plans, or by any similar federal or state program, including a state pharmaceutical assistance program, etc.). Cash-paying patients and Massachusetts patients are eligible but will require a physical Rx savings card.

1Godfrey, AR. Single dose crossover comparative bioavailability study of bupropion hydrochloride 450 mg extended release tablets and Wellbutrin XL® 150 mg extended release tablets in healthy male volunteers under fasting and fed conditions [clinical study report]. Laval, QC: Algorithme Pharma Inc; 2011.

Forfivo XL is a registered trademark of IntelGenx Corp. Wellbutrin XL is a registered trademark of GlaxoSmithKline.